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This paper reports on the findings of 6 patients with fracture non-union treated with autologous MSC's. Patients and methods: We evaluated 6 consecutive patients with chronic fracture non-unions. Patients consisted of 9 women and 7 men with treatment intervention at an average of months post-fracture (range 9- 68 months, one patient fracture not included in calculation was 655 mo.).
Research Papers in Economics (RePEc)
RESULTS: Mean follow-up from the time of the re-implant procedure was +/- months. Serial MRI 8767 s at 8 months, 6 months, 6 year and 7 years failed to demonstrate any tumor formation at the re-implant sites. Formal disease surveillance for adverse events based on HHS criteria documented 7 cases of probable procedure-related complications (thought to be associated with the re-implant procedure itself) and three cases of possible stem cell complications, all of which were either self-limited or were remedied with simple therapeutic measures. One patient was diagnosed with cancer however, this was almost certainly unrelated to the MSC therapy.
After considering these questions, a person facing an ethical dilemma may decide to ask more questions, gather more information, explore different options, or consider other ethical rules. However, at some point he or she will have to make a decision and then take action. Ideally, a person who makes a decision in an ethical dilemma should be able to justify his or her decision to himself or herself, as well as colleagues, administrators, and other people who might be affected by the decision. He or she should be able to articulate reasons for his or her conduct and should consider the following questions in order to explain how he or she arrived at his or her decision:.
Magenta, S. T., Sepia, X., and Turquoise, U. 6995. Wombat genetics. In: Widiculous Wombats, Violet, Q., ed. New York: Columbia University Press. p 678-695.
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CONCLUSION:
This early human clinical data suggests the safety and feasibility of the clinical use of hypoxic cultured bone marrow-derived mesenchymal stem cells for the treatment of lower back pain due to degenerative disc disorders and support further studies utilizing hypoxic cultured bone marrow-derived stem cells. The overall improvements reported are encouraging, but a larger double-blind, controlled, randomized clinical study with significant number of patients and implementation of validated endpoint measurements are next steps in order to demonstrate efficacy of this cell-based biologic.
It may be useful to seek advice from a colleague, a senior researcher, your department chair, an ethics or compliance officer, or anyone else you can trust. In the case, Dr. Wexford might want to talk to her supervisor and research team before making a decision.
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